Synthesis and biological activity of new nitrogen- and oxygen-containing heteroprostanoids based on tetronic acids and cyclopentenoisoxazolines

Purpose: obtaining new promising drugs

Brief description: the synthesis of new nitrogen- and oxygen-containing prostanoids on the basis of cyclopentenoisoxazolines has been developed and carried out, the synthesized samples of new prostanoids were transferred to the biotesting laboratory of the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus for research of biological activity. Some of the compounds obtained for the first time also turned out to be of practical importance as promising stabilizers of polymers or components of liquid crystal mixtures.

Advantages over analogs: cheap and affordable reagents, mild reaction conditions are used in the synthesis of prostanoids as physiologically active compounds, which saves energy

Form of intellectual property protection: patent 8987 RB “Methyl ester of (±) 7-oxo-7 – he[2,2-этилендиокси-5-(диметоксикарбонил-метил)-циклопент-1-ил]ptanoic acid”; Application for invention a 20100028 “Stabilizer for thermal oxidative destruction of polyethylene”

Field of application: medicine, pharmaceutical industry, production of polyethylene products used for work in conditions of constant or short-term exposure to high temperatures